CD Biosynsis is a leading AI enzyme expert with extensive experience in using artificial intelligence to promote enzyme discovery and design. Our team uses evolutionary tracing analysis to extract key information from enzyme sequences, providing valuable insights for the rational design of enzymes with improved properties or new functions.
Overview
The evolutionary trace (ET) is the single most validated approach to identify protein functional determinants and to target mutational analysis, protein engineering, and drug design to the most relevant sites of a protein. In enzymology, it is a method used to identify and analyze functional regions within enzymes. It is based on the concept of evolutionary trace, which assumes that important functional residues in a protein will be preserved throughout evolution due to their essential role in the protein’s function. Through the evolutionary trace analysis, the researchers can obtain important information associated with regions of high functional importance associated with catalytic sites, substrate-binding sites, or other functional domains, and this information can guide experimental studies, such as site-directed mutagenesis, to understand the function and mechanisms of enzymes better.
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